Never seen a pair of plugs that didn't work when inserted properly. Also never seen a pair that would interfere with a pair of earmuffs. I don't think an incompatibility is possible there.
With .22 you can get away with one or the other, especially if you are alone / semi-alone on an outdoor range. Try both, I think you'll decide on the muffs or a combo over just plugs.
I err on the side of caution and always do both as I like to hear and want to keep on doing it.
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